Mait Cell Development

Grant number: 1083942 | Funding period: 2015 - 2017

Completed

Abstract

This project will investigate the factors that regulate the development and maintenance of a recently identified population of white blood cells called MAIT cells. MAIT cells are abundant in humans yet poorly understood. A better understanding of how these cells are regulated, and how they can be targeted in diseases, is necessary if we want to ultimately use these cells for immunotherapy.

Related publications (8)

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Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

2019-05-21

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

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A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

HF Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y D'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nüssing, K Kedzierska

2019-01-01

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

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An overview on the identification of MAIT cell antigens

L Kjer-Nielsen, AJ Corbett, Z Chen, L Liu, JYW Mak, DI Godfrey, J Rossjohn, DP Fairlie, J McCluskey, SBG Eckle

2018-07-01

Mucosal associated invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR..

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Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

Z Chen, H Wang, C D'Souza, S Sun, L Kostenko, SBG Eckle, BS Meehan, DC Jackson, RA Strugnell, H Cao, N Wang, DP Fairlie, L Liu, DI Godfrey, J Rossjohn, J McCluskey, AJ Corbett

2017-01-01

Despite recent breakthroughs in identifying mucosal-associated invariant T (MAIT) cell antigens (Ags), the precise requirements fo..

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Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

CE Teh, N Lalaoui, R Jain, AN Policheni, M Heinlein, S Alvarez-Diaz, JM Sheridan, E Rieser, S Deuser, M Darding, HF Koay, Y Hu, F Kupresanin, LA O'Reilly, DI Godfrey, GK Smyth, P Bouillet, A Strasser, H Walczak, J Silke

2016-11-18

The linear ubiquitin chain assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adaptive ..

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A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

HF Koay, NA Gherardin, A Enders, L Loh, LK Mackay, CF Almeida, BE Russ, CA Nold-Petry, MF Nold, S Bedoui, Z Chen, AJ Corbett, SBG Eckle, B Meehan, Y D'Udekem, IE Konstantinov, M Lappas, L Liu, CC Goodnow, DP Fairlie

2016-10-19

Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting mole..

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The linear ubiquitin chain assembly complex: a new function in thymic T cell differentiation and regulatory T cell homeostasis

C Teh, N Lalaoui, R Jain, A Policheni, M Heinlein, S Alvarez-Diaz, E Rieser, S Deuser, H-F Koay, Y Hu, F Kupresanin, L O'Reilly, D Godfrey, G Smyth, P Bouillet, A Strasser, H Walczak, J Silke, D Gray

2016-08-01

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Lipid and small-molecule display by CD1 and MR1

I Van Rhijn, DI Godfrey, J Rossjohn, DB Moody

2015-10-29

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The anti..

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